What question did this study set out to answer?

To review the pathophysiological mechanisms through which excessive circulating catecholamines and glucocorticoids interact to cause cardiac dysfunction during severe stress.

July 1, 2009Canadian Journal of Physiology and Pharmacology

Role of the excessive amounts of circulating catecholamines and glucocorticoids in stress-induced heart disease

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Authors

AAAdriana AdameováSlovak Academy of Sciences YAYasser AbdellatifAin Shams University Hospital NDNaranjan S. DhallaElectrophysiology

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Implication

Should not change practice; leaves open whether targeting catecholamine pathways improves outcomes in stress cardiomyopathy.

Key Points

To review the pathophysiological mechanisms through which excessive circulating catecholamines and glucocorticoids interact to cause cardiac dysfunction during severe stress.
Narrative synthesis of preclinical and clinical literature investigating sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation.
Evaluation of molecular pathways involving beta-adrenoceptor signaling, cardiomyocyte calcium homeostasis, and catecholamine oxidation products.
Glucocorticoids heighten cardiac sensitivity to catecholamines by inhibiting extraneuronal uptake and upregulating beta-adrenoceptor signal transduction components.
Sustained high levels of catecholamines induce pathological intracellular calcium overload in cardiomyocytes.
Oxidation of catecholamines produces toxic aminolutins and oxyradicals that impair mitochondrial energy synthesis, disrupt sarcoplasmic calcium regulation, and promote coronary spasm and arrhythmias.

Cite This Study

Adameová et al. (2009) studied this question.

synapsesocial.com/papers/6a7e6dca410afd830ac7714a https://doi.org/10.1139/y09-042

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Role of the excessive amounts of circulating catecholamines and glucocorticoids in stress-induced heart disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Role of the excessive amounts of circulating catecholamines and glucocorticoids in stress-induced heart disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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