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July 1, 2001Blood

Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism

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Authors

CUCornelia M. UlrichUniversity of UtahYYYutaka YasuiSt. Jude Children's Research HospitalRSRainer StorbKanazawa University

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Ulrich et al. (2001) studied this question.

synapsesocial.com/papers/6a7e6f618129fc77b4b29efahttps://doi.org/10.1182/blood.v98.1.231
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  2. 2Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide1986 · 208 citations
  3. 3Marrow Transplantation for the Treatment of Chronic Myelogenous Leukemia1986 · 555 citations
  4. 4Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells.1990 · 63 citations