Population
In vitro cultured fibroblasts and in vivo liver models
Comparison
Radiolabeled sucrose covalently linked to protein vs 125I-LDL (for in vitro comparison)
Design
Preclinical
Authors
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Validates sucrose radiolabeling for lysosomal protein degradation assays; leaves open translation to human cardiovascular research.
A novel method using radiolabeled sucrose covalently linked to proteins accurately quantifies lysosomal degradation of plasma proteins, as validated with LDL in vitro and asialofetuin in vivo.
Pittman et al. (1979) studied this question.
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