Population
Saccharomyces cerevisiae (yeast) cells
Design
Preclinical
Authors
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Provides no clinical guidance for spindle defects; leaves open whether analogous mechanisms operate in mammalian mitosis.
Demonstrates that spindle orientation in yeast depends on a Myo2-Kar9-Bim1 complex transporting microtubule ends along polarized actin cables.
Hwang et al. (2003) studied this question.
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