November 1, 2001Journal of the American Society of NephrologyOpen Access

Time-Dependent Autoregulation of Renal Blood Flow in Conscious Rats

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Population

25 male conscious rats

Comparison

Ramp-shaped changes in renal perfusion pressure vs Control (baseline)

Design

Preclinical

Authors

BFBert FlemmingCharité - Universitätsmedizin Berlin NANicole ArenzUniversidad Mayor de San Andrés ESErdmann SeeligerBerlin Institute of Health at Charité - Universitätsmedizin Berlin

Discussion

Member takes

Implication

Dynamic renal perfusion responses in animals suggest hysteresis effects; leaves open relevance to human autoregulation and therapy.

Structured PICO

Population

25 male conscious rats

Intervention

Ramp-shaped changes in renal perfusion pressure (RPP) (decremental followed by incremental ramps at four different rates of change ranging from 0.118 to 1.056 mmHg/s)

Comparator

Control (baseline)

Outcome

Renal blood flow, cortical and medullary fluxes, and relative conductance valuessurrogate

Renal vascular responses to changes in renal perfusion pressure are highly dependent on the dynamics of the error signal, demonstrating a hysteresis-like asymmetry.

Cite This Study

Flemming et al. (2001) studied this question.

synapsesocial.com/papers/6a7e7a1db44705ee46857077 https://doi.org/10.1681/asn.v12112253

View Full Paper

Ask AI

Bookmark

Time-Dependent Autoregulation of Renal Blood Flow in Conscious Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Time-Dependent Autoregulation of Renal Blood Flow in Conscious Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider