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May 1, 1984AJP Renal Physiology

Interaction between neural and nonneural mechanisms controlling renin secretion rate

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Population

Anesthetized vagotomized dogs

Comparison

Left renal nerve stimulation at 0.075, 0.3, or… vs Denervated right kidney and varying levels of…

Design

Preclinical

Authors

UKUlla C. KoppUniversity of IowaGDG. F. DiBonaBrigham and Women's Hospital

Discussion

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Implication

Pressure-dependent neural enhancement of renin secretion in dogs; leaves open relevance to human cardiorenal physiology.

Key Points

  • To determine how renal nerve stimulation and renal arterial pressure interact to regulate the rate of renin secretion.
  • Tested anesthetized, vagotomized dogs across graded renal arterial pressures of 170, 130, 90, and 50 mmHg.
  • Stimulated the left renal nerves at frequencies of 0.075, 0.3, or 0.7 Hz with a denervated contralateral right kidney acting as a control.
  • At spontaneous pressure, renal nerve stimulation at 0.075, 0.3, and 0.7 Hz decreased renal blood flow by 0%, 1 ± 0%, and 2 ± 1%, and urinary sodium excretion by 0%, 2 ± 1%, and 22 ± 3%, respectively.
  • Renal nerve stimulation at 0.075 Hz increased renin secretion only at 50 mmHg (1,806 ± 505 ng/min); 0.3 Hz increased secretion at 50 and 90 mmHg (2,635 ± 824 and 1,197 ± 289 ng/min); and 0.7 Hz increased secretion at 50, 90, and 130 mmHg (1,421 ± 287, 747 ± 172, and 273 ± 163 ng/min), with no increases at 170 mmHg.

Structured PICO

P
Population
Anesthetized vagotomized dogs
I
Intervention
Left renal nerve stimulation (RNS) at 0.075, 0.3, or 0.7 Hz at varying renal arterial pressures (170, 130, 90, and 50 mmHg)
C
Comparator
Denervated right kidney and varying levels of renal arterial pressure/stimulation frequencies
O
Outcome
Renin secretion ratesurrogate

This preclinical study demonstrates that neural and nonneural mechanisms interact to control renin secretion rate, dependent on renal arterial pressure and nerve stimulation intensity.

Cite This Study

Kopp et al. (1984) studied this question.

synapsesocial.com/papers/6a7e7a1eb44705ee4685707chttps://doi.org/10.1152/ajprenal.1984.246.5.f620
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective Stimulation of Renal Nerves in the Anesthetized Dog1973 · 99 citations
  2. 2Mechanism of renin release during renal nerve stimulation in dogs1981 · 28 citations
  3. 3Interaction Between Norepinephrine Release and Intrarenal Angiotensin II Formation During Renal Nerve Stimulation in Dogs2000 · 8 citations
  4. 4Neural and vascular interaction in renin response to graded renal nerve stimulation1982 · 24 citations
  5. 5Role of macula densa in renal nerve modulation of renin secretion1982 · 17 citations