October 1, 2012Cardiovascular ResearchOpen Access

Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways

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Why the study?

Does Rac1 inhibition prevent doxorubicin-induced cardiotoxicity in preclinical models?

Population

Mouse model of acute doxorubicin-induced cardiotoxicity, rat cardiomyoblasts, and cultured neonatal mouse…

Comparison

Cardiomyocyte-specific deletion of Rac1… vs Control (wild-type mice or untreated cells)

Design

Preclinical

Authors

JMJian MaDalian Medical University YWYanpeng WangHenan Polytechnic University WMWei MengJinan Central Hospital

Discussion

Member takes

Implication

Rac1 inhibition attenuates doxorubicin cardiotoxicity in mice; leaves open translation to human cardioprotection.

Structured PICO

Does Rac1 inhibition prevent doxorubicin-induced cardiotoxicity in preclinical models?

Population

Mouse model of acute doxorubicin-induced cardiotoxicity, rat cardiomyoblasts (H9c2 cells), and cultured neonatal mouse cardiomyocytes

Intervention

Cardiomyocyte-specific deletion of Rac1, specific Rac1 inhibitor NSC23766, or overexpression of Rac1

Comparator

Control (wild-type mice or untreated cells)

Outcome

Cardiotoxicity (NADPH oxidase activation, ROS production, cardiac cell death, myocardial function, apoptosis)surrogate

Rac1 inhibition protects against doxorubicin-induced cardiotoxicity via both ROS-dependent and ROS-independent (HDAC/p53) pathways, suggesting a potential therapeutic target.

Cite This Study

Ma et al. (2012) studied this question.

synapsesocial.com/papers/6a7e7ad4bf2fd941fe8f52ae https://doi.org/10.1093/cvr/cvs309

Topics

Bremelanotide

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Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider