What question did this study set out to answer?

To assess whether loop diathermy excision of the transformation zone and laser vaporisation are equally effective for treating cervical intraepithelial neoplasia.

April 1, 2002BJOG An International Journal of Obstetrics & Gynaecology

Loop diathermy excision compared with cervical laser vaporisation for the treatment of intraepithelial neoplasia: a randomised controlled trial

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To assess whether loop diathermy excision of the transformation zone and laser vaporisation are equally effective for treating cervical intraepithelial neoplasia.
Multicenter randomized controlled trial conducted across seven colposcopy units in the North West Region involving 289 women referred for abnormal cytology.
Participants suitable for outpatient local destructive treatment were randomized to either loop diathermy excision of the transformation zone or laser vaporisation, with 285 women followed by post-treatment smears.
Laser vaporisation significantly increased the risk of post-treatment moderate dyskariosis or worse compared with loop diathermy excision (hazard ratio 3.01, 95% CI 1.27 to 7.12).
Cumulative risk of moderate dyskariosis or worse was 6.0% at six months and 12.1% at three years for laser vaporisation, compared with 2.0% at six months and 3.3% at three years for loop diathermy excision.

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Implication

Randomized trial reveals higher treatment failure rates with laser vaporisation in women with cervical intraepithelial neoplasia, indicating superior efficacy for loop diathermy excision.

Cite This Study

Dey et al. (2002) studied this question.

synapsesocial.com/papers/6a7e7b1cfff18652e232fe0a https://doi.org/10.1111/j.1471-0528.2002.01277.x

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Implication

Randomized trial reveals higher treatment failure rates with laser vaporisation in women with cervical intraepithelial neoplasia, indicating superior efficacy for loop diathermy excision.

Loop diathermy excision compared with cervical laser vaporisation for the treatment of intraepithelial neoplasia: a randomised controlled trial

Key Points

Discussion

Implication

Cite This Study

Loop diathermy excision compared with cervical laser vaporisation for the treatment of intraepithelial neoplasia: a randomised controlled trial

Key Points

Discussion

Implication

Cite This Study

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