Randomised placebo controlled trial of effect on mood of lowering cholesterol concentration
Why the study?
Does simvastatin cause mood disturbance in patients at high risk of coronary heart disease?
Population
621 men and women aged 40 to 75 years with blood total cholesterol ≥3.5 mmol/l, at higher than average risk…
Comparison
Simvastatin 20 mg or 40 mg daily vs Matching placebo
Design
RCT, 2:1 ratio (simvastatin to placebo), Placebo-controlled
Follow-up
average of 152 weeks
Authors
Discussion
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Implication
No mood disturbance risk with simvastatin in high-risk CHD patients; confirms cholesterol reduction is mood-neutral.
Structured PICO
Does simvastatin cause mood disturbance in patients at high risk of coronary heart disease?
P
Population
621 men and women aged 40 to 75 years with blood total cholesterol ≥3.5 mmol/l, at higher than average risk of coronary heart disease (with cardiovascular disease and no pre-existing psychiatric conditions).
I
Intervention
Simvastatin 20 mg or 40 mg daily
C
Comparator
Matching placebo
O
Outcome
Shortened profile of mood states questionnaire, reported use of psychotropic medication, and symptoms possibly related to mood at an average of 152 weekspatient reported
Substantial and prolonged reduction in total cholesterol with simvastatin does not cause mood disturbance in patients at high risk of coronary heart disease.
Cite This Study
Armitage et al. (1996) studied this question.