Key result
Acute transmural MI is linked to marked SGOT elevations in ~99% of patients.
Observational (n=75)
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The serum glutamic oxalacetic transaminase rose two to 20 times normal in 74 of 75 patients who had acute transmural myocardial infarction. The height of the enzymatic activity was roughly proportional to the size of the infarct. Serum glutamic oxalacetic transaminase is unaffected by angina pectoris, coronary insufficiency, heart failure, or digitalis in the absence of active heart cell injury. Experimental myocardial infarction is followed consistently by a two to twenty-fold increase in serum glutamic oxalacetic transaminase activity. Increase in the serum activity of this enzyme appears to be a useful index of the presence of active heart muscle injury.
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LaDue et al. (1955) conducted an observational in Acute transmural myocardial infarction (n=75). Serum glutamic oxalacetic transaminase activity vs. Angina pectoris, coronary insufficiency, heart failure, or digitalis without active heart cell injury was evaluated on Two to 20 times normal increase in serum glutamic oxalacetic transaminase activity. Serum glutamic oxalacetic transaminase activity rose 2 to 20 times normal in 98.7% (74/75) of patients with acute transmural myocardial infarction.
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