Global left atrial dysfunction and regional heterogeneity in primary chronic mitral insufficiency

84 subjects, comprising 43 patients with chronic primary mitral regurgitation (MR) secondary to myxomatous mitral valve disease (MMVD) and normal left ventricular systolic function, and 41 normal control subjects.

Normal control subjects (n=41)

Global and regional left atrial (LA) function assessed by velocity vector imaging (atrial volumes, ejection fraction, velocities, and strain/strain rate)surrogate