April 1, 2002Journal of Biological ChemistryOpen Access

Two Adaptor Proteins Differentially Modulate the Phosphorylation and Biophysics of Kv1.3 Ion Channel by Src Kinase

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Population

HEK 293 cells and olfactory bulb tissue expressing Kv1.3 ion channels

Comparison

Co-expression of Kv1.3 and v-Src kinase with… vs Expression of Kv1.3 and v-Src kinase without…

Design

Preclinical

Authors

KCKaren K. CookPfizer (United States)DFDebra Ann FadoolFlorida State University

Discussion

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Implication

Hypothesis-generating for Kv1.3 regulation in cardiac models; prospective validation required before clinical consideration.

Structured PICO

Population

HEK 293 cells and olfactory bulb tissue expressing Kv1.3 ion channels

Intervention

Co-expression of Kv1.3 and v-Src kinase with adaptor proteins Grb10 or n-Shc (including mutant variants)

Comparator

Expression of Kv1.3 and v-Src kinase without adaptor proteins, or with wild-type versus mutant adaptor proteins

Outcome

Kv1.3 tyrosine phosphorylation levels and biophysical properties (current magnitude, inactivation time constant, cumulative inactivation, voltage dependence)surrogate

The adaptor proteins Grb10 and n-Shc differentially regulate the phosphorylation and biophysical properties of the Kv1.3 ion channel mediated by Src kinase.

Cite This Study

Cook et al. (2002) studied this question.

synapsesocial.com/papers/6a7e7f66b2811efa75cd9af9 https://doi.org/10.1074/jbc.m108898200

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Two Adaptor Proteins Differentially Modulate the Phosphorylation and Biophysics of Kv1.3 Ion Channel by Src Kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Two Adaptor Proteins Differentially Modulate the Phosphorylation and Biophysics of Kv1.3 Ion Channel by Src Kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider