Luteinizing Hormone and Follicle-Stimulating Hormone Secretory Dynamics in Turner's Syndrome*

In eight teenage patients with Turner's syndrome, LH and FSH were measured at 20-min intervals for 24 h. The 24-h mean LH and FSH levels ranged from 20.2–70.5 mlU/ml and 60.4–229 mlU/ml, respectively. There was a significant positive correlation between the individual LH and FSH levels in the eight patients; the common correlation coefficient was 0.449 (P < 0.001). The 24-h mean estradiol level was measurable in only two of the patients and the 24-h mean testosterone level for the eight patients was 0.10 ng/ml. The mean LH concentration during sleep was significantly higher (P < 0.01) than during waking. The mean FSH concentration during sleep was also significantly higher (P < 0.05) than during waking. The LH and FSH peak levels after LRH were significantly correlated with the 24-h mean LH (r = 0.918; P < 0.01) and FSH concentrations (r = 0.754; P < 0.05), respectively.