Why the study?
Switching from conventional to high-sensitivity cardiac troponin assays enables detection of smaller amounts of myocardial damage, but the clinical benefit was unclear.
Does switching to a high-sensitivity cardiac troponin I assay reduce 1-year death or new MI in patients with suspected acute coronary syndrome?
Population
179 681 consecutive patients >=20 years old presenting to EDs with suspected ACS
Comparison
Switching to hs-cTnI assay with sex-specific 99th centile diagnostic threshold vs conventional troponin assays
Design
Multicentre pre-post study
Follow-up
1 year
Authors
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Switching to hs-cTnI was associated with lower mortality; leaves open whether randomized trials would confirm benefit before practice change.
Does switching to a high-sensitivity cardiac troponin I assay reduce 1-year death or new MI in patients with suspected acute coronary syndrome?
The transition to high-sensitivity cardiac troponin I assays for evaluating suspected ACS in the emergency department is associated with a significant reduction in 1-year mortality.
Hickling et al. (2025) studied this question.
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