What question did this study set out to answer?

To determine whether Xuebijing injection reduces 28-day mortality compared with placebo in patients with sepsis.

May 1, 2023JAMA Internal MedicineOpen Access

Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis

View Full Paper

Ask AI

Bookmark

Authors

SLSongqiao LiuNational Natural Science Foundation of China CYChen YaoSun Yat-sen University JXJianfeng XieFujian Medical University

Discussion

Member takes

Implication

Randomized double-blind trial demonstrates reduced 28-day mortality with Xuebijing injection in sepsis patients, indicating potential survival benefits.

Key Points

To determine whether Xuebijing injection reduces 28-day mortality compared with placebo in patients with sepsis.
Multicenter, randomized, double-blind, placebo-controlled trial (EXIT-SEP; NCT03238742) conducted across 45 intensive care unit sites enrolling 1817 patients aged 18 to 75 years with sepsis present for less than 48 hours and a SOFA score of 2 to 13.
Participants were randomly assigned to receive either intravenous Xuebijing injection (100 mL, n = 911) or volume-matched saline placebo (n = 906) every 12 hours for 5 days, with 28-day follow-up.
Among the 1760 patients who completed the trial, 28-day mortality was significantly lower in the Xuebijing group compared with the placebo group (165 of 878 [18.8%] vs 230 of 882 [26.1%]; absolute risk difference, 7.3 percentage points [95% CI, 3.4-11.2]; P < .001).
Adverse events occurred in 200 of 872 patients (22.9%) receiving Xuebijing compared with 222 of 878 patients (25.3%) receiving placebo.

Cite This Study

Liu et al. (2023) studied this question.

synapsesocial.com/papers/6a7e8463ec6d7e203fcd9ba9 https://doi.org/10.1001/jamainternmed.2023.0780

View Full Paper

Ask AI

Bookmark

Implication

Randomized double-blind trial demonstrates reduced 28-day mortality with Xuebijing injection in sepsis patients, indicating potential survival benefits.

Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider