Answers are grounded in this paper and cite their sources.
Several pairs of cannabinoid isomers were synthesized and tested for psychotropic activity in rhesus monkeys. Two regularities were observed: (a) In the absence of the other substituents, the equatorial stereochemistry of the substituent at C-1 determines activity. (b) Two groups of THC-type cannabinoids which differ only in that the chemical groupings in one of them at C-1, C-2 are situated at C-1, C-6 in the other (but retain their stereochemistry) have almost equivalent psychotropic activity.
No takes yet. Share an insight, caveat, or question.
Mechoulam et al. (1980) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: