Why the study?
Decreased junctophilin-2 has been linked to heart failure, but its transcriptional regulation and role in maintaining excitation-contraction coupling efficiency remain to be clarified.
The up-regulation of myocardin boosts junctophilin-2 and caveolin-3 expression, enhancing excitation-contraction coupling in hibernating ground squirrels, offering a potential strategy to correct deficient Ca2+ signaling in heart failure.
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Myocardin-SRF regulation may sustain junctophilin-2 in cardiac stress; leaves open therapeutic targeting in heart failure.
Yang et al. (2021) studied this question.
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