Key result
Cardiac-specific knockdown of junctophilin-2 in mice resulted in impaired cardiac contractility, heart failure, increased mortality, and loss of excitation-contraction coupling gain.
Authors
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Junctophilin-2 loss drives heart failure in mice; animal data leave open therapeutic targeting and human translation.
Oort et al. (2011) studied Heart failure / impaired cardiac contractility. Cardiac-specific JPH2 knockdown using RNA interference was evaluated on Cardiac contractility, heart failure, mortality, and excitation-contraction coupling. Cardiac-specific knockdown of junctophilin-2 in mice resulted in impaired cardiac contractility, heart failure, increased mortality, and loss of excitation-contraction coupling gain.
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