Population
Human cardiac tissue from patients with hypertrophic cardiomyopathy and ostensibly healthy traumatic death…
Comparison
Partial silencing of JPH2 expression using a… vs Healthy human cardiac tissue; non-silenced HL-1…
Design
Preclinical
Authors
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JPH2 reduction may contribute to HCM hypertrophy and Ca2+ dysregulation; hypothesis-generating in human tissue and cells, leaves open therapeutic targeting.
JPH2 levels are reduced in patients with hypertrophic cardiomyopathy, and its downregulation in vitro causes prohypertrophic remodeling and altered calcium homeostasis.
Landstrom et al. (2011) studied this question.
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