Seeing the light: The use of a coupled assay with bacterial luciferase results in a common light-emission screen for a variety of potential biotransformations. Screening the E. coli proteome for the oxidation of simple alcohols to good and bad luciferase substrates reveals examples of substrate ambiguity and catalytic promiscuity. Reactions leading to aldehydes can easily be screened by this method.
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Krebs et al. (2005) studied this question.
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