Why the study?
The study evaluated 123I-MIBG myocardial scintigraphy in the subacute phase of AMI to predict cardiac events, particularly in patients who successfully responded to reperfusion therapy.
Does 123I-MIBG myocardial scintigraphy predict long-term cardiac events in patients with acute myocardial infarction after successful reperfusion therapy?
Does 123I-MIBG myocardial scintigraphy predict long-term cardiac events in patients with acute myocardial infarction after successful reperfusion therapy?
123I-MIBG myocardial scintigraphy parameters, specifically washout rate and H/M ratio, can predict long-term cardiac events in patients recovering from acute myocardial infarction after reperfusion therapy.
OBJECTIVES: I-MIBG myocardial scintigraphy in subacute phase of acute myocardial infarction (AMI) in the prediction of cardiac events, particularly in patients who are successfully responded to reperfusion therapy. METHODS: I-MIBG administration, an anterior planar delayed SPECT image was obtained. The H/M ratio and WR were calculated based on planar images. In addition, the average WR, defect volume, and extent were calculated from the SPECT image. The end points of the cardiac event was defined as hospitalization due to unstable angina, heart failure progression, myocardial infarction recurrence, malignant arrhythmia and cardiac death. RESULTS: The follow-up period was 18.4±8.5 months on average, during which 38 (26.2%) cases experienced cardiac events. The results revealed a significant difference between the groups with and without cardiac events in terms of WR and WR (SPECT). Based on the multivariate analysis, WR was the only relevant factor predicting cardiac events. The cumulative event-free rate was significantly lower in the group with the delayed H/M ratio of < 1.74. The cumulative event-free rate were significantly lower in the groups with WR and WR (SPECT) more than 25% and 21.8%, respectively. There was no significant relationship between the cumulative event-free survival rate and the defect size. CONCLUSION: I-MIBG from the myocardium in planar scintigraphy and SPECT is the predictor of heart failure and cardiac events such as myocardial infarction and recurrence of unstable angina.
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Nakamura et al. (2019) studied this question.
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