December 1, 1996Angiology
Thrombogenesis in Mitral Regurgitation and Aortic Stenosis
Why the study?
Do patients with mitral regurgitation or aortic stenosis have abnormal plasma fibrinogen or fibrin D-dimer levels compared to normal population controls?
Population
25 patients with valve disease in sinus rhythm, including 12 with mitral regurgitation and 13 with aortic…
Comparison
Mitral regurgitation (MR) or aortic stenosis (AS) vs Normal population controls
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Does not support changing management in MR or AS; leaves open fibrinogen's role in valvular thrombosis risk.
Structured PICO
Do patients with mitral regurgitation or aortic stenosis have abnormal plasma fibrinogen or fibrin D-dimer levels compared to normal population controls?
P
Population
25 patients with valve disease in sinus rhythm, including 12 with mitral regurgitation (all women, mean age 55 years) and 13 with aortic stenosis (7 men, 6 women, mean age 57 years).
I
Intervention
Mitral regurgitation (MR) or aortic stenosis (AS)
C
Comparator
Normal population controls
O
Outcome
Plasma fibrinogen and fibrin D-dimer levelssurrogate
Patients with mitral regurgitation and aortic stenosis exhibit elevated plasma fibrinogen levels, suggesting a prothrombotic state, though D-dimer patterns differ between the two conditions.
Cite This Study
Lip et al. (1996) studied this question.