Detergent-treated rabbit taenia coli smooth muscle can develop tension comparable to intact muscle when exposed to calcium or magnesium.
Skinned smooth muscle retains full contractile capacity; extends in vitro models but leaves open translation to cardiac physiology or practice.
After exposure of segments of rabbit taenia coli to the nonionic detergent Triton X-100, tension could be induced by increasing the [Ca2+] in the micromolar range. In the presence of a saturating [Ca2+], this preparation developed nearly 100% of the control tetanus tension recorded from the intact muscle prior to the detergent treatment. In addition, tension could be induced by increasing the [Mg2+], in the virtual absence of Ca2+. Mg2+ seems to inhibit the Ca2+-induced tension in a predominantly competitive manner.
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AR Gordon (1978) studied this question.
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