Endocrine states such as hyperthyroidism and type-2 diabetes significantly alter fat cell number and lipid synthesis in rat retroperitoneal adipose tissue.
Answers are grounded in this paper and cite their sources.
Rat model findings on adipose hyperplasia and lipogenesis in hyperthyroidism or diabetes should not change practice; leaves open human translation.
The incorporation rate of 3H from 3H2O in the total lipids of rat retroperitoneal adipose tissue (RPAT) according to age was followed in slightly hyperthyroid rats, in type-2 diabetic rats and in control rats. Until 12 weeks of age, the RPAT of the hyperthyroid animals exhibited hyperplasia and an increase in lipogenesis per g of wet weight or per whole fat pad. Fat cel number and lipogenesis per g of wet weight or per whole fat pad were reduced in adult diabetic rats. The concomitant changes in fat cell number and lipid synthesis in the RPAT of the two groups of treated rats have been discussed.
No takes yet. Share an insight, caveat, or question.
Levacher et al. (1985) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: