Key result
Cold exposure in rats prevents age-related adipocyte increases except for supranormal growth in epididymal depots.
Population
Male Sprague-Dawley rats
Design
Preclinical
Follow-up
up to 24 weeks
Authors
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Rat data show cold alters adipocyte numbers depot-specifically; leaves open relevance to human obesity or metabolic disease.
Cold exposure in rats induces depot-specific variations in adipocyte proliferation, contrasting with diet-induced hyperplasia patterns.
Miller et al. (1982) studied this question. 5 degrees C environment (cold exposure) vs. Normal age-related changes was evaluated on cellularity of major adipose depots (adipocyte number). Cold exposure (5°C) in male rats for up to 24 weeks prevented normal age-related increases in adipocyte number in retroperitoneal and inguinal depots, but caused a supranormal increase in epididymal depots.
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