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December 1, 1977Proceedings of the National Academy of SciencesOpen Access

Demonstration of different contractile mechanisms for angiotensin II and des-Asp1-angiotensin II in rabbit aortic strips.

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Population

Rabbit aortic strips

Comparison

Angiotensin peptides and norepinephrine vs Different calcium availability conditions

Design

Preclinical

Authors

JAJohn A. AckerlyCleveland ClinicAMAlan F. MooreKnoxville CollegeMPM J PeachLancaster University

Discussion

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Overview

Ang III engages calcium-independent contraction unlike Ang II in rabbit aorta; leaves open relevance to human vascular physiology or therapy.

Structured PICO

P
Population
Rabbit aortic strips
I
Intervention
Angiotensin peptides (Angiotensin II, [Sar1]Ang II, Angiotensin III) and norepinephrine
C
Comparator
Different calcium availability conditions (treatment with SKF-525A, verapamil, or Ca2+-free buffer)
O
Outcome
Contractile responses and extracellular Ca2+ requirementsurrogate

Angiotensin III and Angiotensin II utilize different contractile mechanisms in rabbit aortic strips, with Ang III acting independently of extracellular calcium.

Cite This Study

Ackerly et al. (1977) studied this question.

synapsesocial.com/papers/6a7e90cc24fafc1ad4ea44aehttps://doi.org/10.1073/pnas.74.12.5725
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inotropic Agents in Hypoxic Cat Myocardium1972 · 35 citations
  2. 2Angiotensin antagonists with increased specificity for the renal vasculature.1977 · 37 citations
  3. 3Vascular Smooth Muscle: Dual Effect of Calcium1963 · 285 citations
  4. 4Role of converting enzyme in the responses of rabbit atria, aortas, and adrenal zona glomerulosa to [des-Asp1]angiotensin I.1977 · 22 citations
  5. 5ACTION OF [1-DES(ASPARTIC ACID), 8-ISOLEUCINE] ANGIOTENSIN II UPON THE PRESSOR AND STEROIDOGENIC ACTIVITY OF ANGIOTENSIN II.1975 · 36 citations