January 1, 2012Military MedicineOpen Access

Exertional Sickling Deaths in Army Recruits With Sickle Cell Trait

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Population

Two U.S. Army recruits with undetected sickle cell trait (SCT)

Design

Case_series

Authors

Discussion

Undetected SCT warrants caution in intense exercise; case reports leave screening recommendations open.

Population

Two U.S. Army recruits with undetected sickle cell trait (SCT)

Intervention

Intense exercise (2-mile run of the Army Physical Fitness Test)

Outcome

Death from metabolic complications of exertional sickling (fulminant rhabdomyolysis)hard clinical

Intense exercise can trigger fatal exertional sickling and fulminant rhabdomyolysis in individuals with undetected sickle cell trait.

Ferster et al. (2012) studied this question.

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