August 15, 2014Journal of the American Heart AssociationOpen Access

Lack of Angiopoietin‐Like‐2 Expression Limits the Metabolic Stress Induced by a High‐Fat Diet and Maintains Endothelial Function in Mice

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Why the study?

Does angptl2 knockdown prevent high-fat diet-induced endothelial dysfunction and metabolic stress in mice?

Population

Wild-type (WT) and angiopoietin-like-2 (angptl2) knockdown (KD) mice

Comparison

Angptl2 knockdown and 3-month high-fat diet vs Wild-type (WT) mice on 3-month high-fat diet (HFD)

Design

Preclinical

Follow-up

3 months

Authors

CYCarol YuHong Kong Polytechnic University XLXiaoyan LuoChinese Academy of Tropical Agricultural Sciences NFNada FarhatUniversity of Michigan

Discussion

Member takes

Implication

Angptl2 may be a target in diet-induced endothelial dysfunction; leaves open human translation from this animal model.

Structured PICO

Does angptl2 knockdown prevent high-fat diet-induced endothelial dysfunction and metabolic stress in mice?

Population

Wild-type (WT) and angiopoietin-like-2 (angptl2) knockdown (KD) mice

Intervention

Angptl2 knockdown (genetic model) and 3-month high-fat diet (HFD)

Comparator

Wild-type (WT) mice on 3-month high-fat diet (HFD)

Outcome

Endothelial function (acetylcholine-mediated vasodilation) and metabolic stress markers (lipid profiles, fat accumulation, inflammatory gene expression)surrogate

Knockdown of angptl2 protects mice against high-fat diet-induced endothelial dysfunction and metabolic stress.

Cite This Study

Yu et al. (2014) studied this question.

synapsesocial.com/papers/6a7e91d4e26ba2240a9a10c4 https://doi.org/10.1161/jaha.114.001024

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August 15, 2014Journal of the American Heart AssociationOpen Access

Lack of Angiopoietin‐Like‐2 Expression Limits the Metabolic Stress Induced by a High‐Fat Diet and Maintains Endothelial Function in Mice

View Full Paper

Ask AI

Bookmark

Why the study?

Does angptl2 knockdown prevent high-fat diet-induced endothelial dysfunction and metabolic stress in mice?

Population

Wild-type (WT) and angiopoietin-like-2 (angptl2) knockdown (KD) mice

Comparison

Angptl2 knockdown and 3-month high-fat diet vs Wild-type (WT) mice on 3-month high-fat diet (HFD)

Design

Preclinical

Follow-up

3 months

Authors

CYCarol YuHong Kong Polytechnic University XLXiaoyan LuoChinese Academy of Tropical Agricultural Sciences NFNada FarhatUniversity of Michigan

Discussion

Member takes

Implication

Angptl2 may be a target in diet-induced endothelial dysfunction; leaves open human translation from this animal model.

Structured PICO

Does angptl2 knockdown prevent high-fat diet-induced endothelial dysfunction and metabolic stress in mice?

Population

Wild-type (WT) and angiopoietin-like-2 (angptl2) knockdown (KD) mice

Intervention

Angptl2 knockdown (genetic model) and 3-month high-fat diet (HFD)

Comparator

Wild-type (WT) mice on 3-month high-fat diet (HFD)

Outcome

Endothelial function (acetylcholine-mediated vasodilation) and metabolic stress markers (lipid profiles, fat accumulation, inflammatory gene expression)surrogate

Knockdown of angptl2 protects mice against high-fat diet-induced endothelial dysfunction and metabolic stress.

Cite This Study

Yu et al. (2014) studied this question.

synapsesocial.com/papers/6a7e91d4e26ba2240a9a10c4 https://doi.org/10.1161/jaha.114.001024

Also Consider

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