Population
Bovine aortic endothelial cells, purified human eNOS protein, and C99A eNOS mutant enzyme
Comparison
Exposure to exogenous NO donors or… vs Control conditions or presence of thioredoxin…
Design
Preclinical
Authors
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May indicate NO autoregulation of eNOS; hypothesis-generating and requires human validation before clinical relevance.
This study demonstrates that NO inhibits eNOS activity by inducing S-nitrosylation of cysteine residues, which destroys the zinc tetrathiolate cluster and causes enzyme monomerization.
Ravi et al. (2004) studied this question.
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