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It is possible that the virus formed in infected tissue derives from an abnormal sequence of some normal metabolic processes of the cell.Thus those enzymatic reactions which lead to the formation of cellular components may also be involved in viral synthesis.One approach to this problem of viral biogenesis is to determine which enzyme systems of the host cell are essential to the process.It is from this view-point that consideration is given in the following study to the relation of certain oxidative reactions of the Krebs cycle to the production of influenza virus.
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W. W. Ackermann (1951) studied this question.
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