Why the study?
Does fixed plasma aldosterone concentration prevent equilibration of 24-h Na and water balances during long-term reduction of renal perfusion pressure in beagle dogs?
Population
Chronically instrumented, freely moving beagle dogs kept under standardized conditions
Comparison
Long-term reduction of renal perfusion pressure… vs Control without rRPP
Design
Preclinical
Follow-up
4 consecutive days
Authors
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Supports RAAS downregulation as key for Na equilibration during reduced renal perfusion in dogs; leaves open translation to human cardiorenal syndromes.
Does fixed plasma aldosterone concentration prevent equilibration of 24-h Na and water balances during long-term reduction of renal perfusion pressure in beagle dogs?
Endogenous downregulation of the renin-angiotensin-aldosterone system is a pivotal compensatory mechanism to reduce Na and water retention during reduced renal perfusion pressure.
Seeliger et al. (1997) studied this question.
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