Population
Lipoproteins of density d < 1.063
Comparison
Polyanion-cation precipitation methods for… vs Ultracentrifugation
Design
Preclinical
Authors
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Precipitation methods risk artifactual ApoE patterns; leaves open need for validated isolation protocols in phenotyping studies.
Two-dimensional techniques should be applied for definitive apolipoprotein E phenotyping if precipitated lipoproteins are used as source material to avoid interference by pro-apolipoprotein A-I.
Rawlings et al. (1988) studied this question.