Population
Frog ventricle (superfused preparation)
Comparison
Adrenaline (1 x 10(-6) g/ml) vs Control values (without adrenaline)
Design
Preclinical
Authors
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May reduce Ca permeability in frog ventricle contractures; hypothesis-generating for local Ca stores in inotropy, no clinical translation yet.
Adrenaline decreases contracture tension in frog ventricles, suggesting it decreases calcium permeability while its inotropic action on twitch tension may rely on local calcium stores.
Graham et al. (1968) studied this question.
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