Why the study?
Does 68Ga-FAPI PET/CT improve the detection of lesions in intestinal tuberculosis compared to 18F-FDG PET/CT?
Does 68Ga-FAPI PET/CT improve the detection of lesions in intestinal tuberculosis compared to 18F-FDG PET/CT?
68Ga-FAPI PET/CT may offer superior sensitivity in detecting peritoneal involvement in intestinal tuberculosis compared to standard 18F-FDG PET/CT.
May better map peritoneal TB than FDG; leaves open diagnostic utility pending larger studies.
A 28-year-old woman presented with abdominal pain, bowel dysfunction, and weight loss for 3 months. 18F-FDG PET/CT revealed multiple hypermetabolic lesions in the intestines and peritoneal thickening/caking with moderate FDG activity. 68Ga-FAPI PET/CT showed intense FAPI uptake in the aforementioned FDG-avid lesions and a larger number of abnormal foci with intense FAPI uptake in the peritoneum than that shown in 18F-FDG images. Endoscopy-guided biopsy from the colonic mucosa was consistent with tuberculosis. The positive findings of 68Ga-FAPI in the current case highlighted that 68Ga-FAPI may have value in the evaluation of intestinal tuberculosis.
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A 2021 study studied this question.
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