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Monkeys were exposed to single 2-hr insults of 10, 15, 35, and 50 ppm NO/sub 2/. At lower concentrations tidal volume decreased but returned to normal in 1 to 2 days. Two higher exposures increased respiratory rate and decreased tidal volume, effects which lasted 2 to 3 days. 50 ppm NO/sub 2/ plus bacterial challenge produced mortality. Lower concentrations of NO/sub 2/ reduced or eliminated lung bacterial clearance.
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Henry et al. (1969) studied this question.
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