Clinical experience in over 500 patients scanned with 99mTc-diphosphonate is discussed. In comparison with 18F scans and roentgen studies, 99mTc-diphosphonate has produced similar or better studies. Frequently, the diphosphonate scan is more sensitive, especially in the detection of metastases to bone. In addition, calcific soft-tissue deposits and urinary tract pathology have been visualized on 99mTc-diphosphonate scans. Scanning with 99mTc-diphosphonate is considered to be the most effective imaging modality available for determining the presence and extent of skeletal metastases.
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Pendergrass et al. (1973) studied this question.
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