January 1, 1988Clinical and Experimental Hypertension

Influence of Angiotensin II (AII) and Angiotensin I (AI) on Renal Renin Synthesis and Release

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Why the study?

Does exogenous Angiotensin II or Angiotensin I affect renin synthesis and release in rats receiving oral enalapril?

Population

Rats receiving oral enalapril

Comparison

Exogenous Angiotensin II or Angiotensin II +… vs Oral enalapril alone

Design

Preclinical

Follow-up

7 days

Authors

GBGraham L. BarrettInternational Islamic University Malaysia TMTrefor MorganUniversity of Mississippi Medical Center MSMichelle J. SmithMonash University

Discussion

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Implication

Exogenous AII may blunt enalapril-induced renin rise in rats; hypothesis-generating and should not yet change practice in humans.

Structured PICO

Does exogenous Angiotensin II or Angiotensin I affect renin synthesis and release in rats receiving oral enalapril?

Population

Rats receiving oral enalapril

Intervention

Exogenous Angiotensin II (AII) or Angiotensin II + Angiotensin I (AII + AI) via osmotic minipumps over a 7-day period

Comparator

Oral enalapril alone

Outcome

Renin synthesis and release (plasma and renal renin)surrogate

Exogenous Angiotensin II, but not Angiotensin I, abolishes the enalapril-induced increase in renin synthesis and release in a rat model.

Cite This Study

Barrett et al. (1988) studied this question.

synapsesocial.com/papers/6a7eac8e061146f178a6c555 https://doi.org/10.1080/07300077.1988.11878918

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Influence of Angiotensin II (AII) and Angiotensin I (AI) on Renal Renin Synthesis and Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Influence of Angiotensin II (AII) and Angiotensin I (AI) on Renal Renin Synthesis and Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider