June 1, 1990HypertensionOpen Access

Rat brain natriuretic peptide. Isolation from rat heart and tissue distribution.

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Population

500 rats (atrial tissues)

Design

Preclinical

Authors

Discussion

Positions BNP as a novel cardiac hormone in rats; leaves open its relevance to human hypertension.

Population

500 rats (atrial tissues)

Intervention

Isolation and sequencing of rat brain natriuretic peptide

Outcome

Amino acid sequence and tissue distribution of the 5,000 d cardiac natriuretic peptidesurrogate

The study isolated and sequenced rat brain natriuretic peptide from the heart, identifying it as a novel cardiac hormone.

Nakao et al. (1990) studied this question.

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