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October 27, 2016Journal of Nuclear MedicineOpen Access

Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer ⁶⁸Ga-Pentixafor for PET

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Why the study?

Does 68Ga-pentixafor PET imaging detect CXCR4 expression in atherosclerotic plaques in an experimental rabbit model?

Population

7 rabbits with atherosclerotic plaques induced by endothelial abrasion of the right carotid artery and…

Comparison

68Ga-pentixafor injection followed by PET/MR… vs Normal control arteries in noninjured rabbits…

Design

Preclinical

Follow-up

1 hour after injection

Authors

FHFabien HyafilCardiac Imaging JPJaroslav PelisekUniversity of Zurich ILIina LaitinenUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Supports 68Ga-pentixafor PET/MR plaque imaging in rabbits; leaves open human translation and clinical utility.

Structured PICO

Does 68Ga-pentixafor PET imaging detect CXCR4 expression in atherosclerotic plaques in an experimental rabbit model?

P

Population

7 rabbits with atherosclerotic plaques induced by endothelial abrasion of the right carotid artery and abdominal aorta fed an atherogenic diet, and 5 noninjured rabbits fed a chow diet as controls (total n=12).

I

Intervention

68Ga-pentixafor (15 MBq/kg) injection followed by PET/MR imaging, and 125I-pentixafor (7.5 MBq/kg) for biodistribution and autoradiographic studies.

C

Comparator

Normal control arteries in noninjured rabbits fed a chow diet.

O

Outcome

Vascular signal quantified as tissue-to-background ratio (TBR) to detect CXCR4 expression on inflammatory cells in atherosclerotic plaques.surrogate

68Ga-pentixafor allows for noninvasive detection of CXCR4 expression in atherosclerotic plaques with PET, offering a potential alternative to 18F-FDG for assessing macrophage infiltration.

Cite This Study

Hyafil et al. (2016) studied this question.

synapsesocial.com/papers/6a7eb3bee26ba2240a9a1565 https://doi.org/10.2967/jnumed.116.179663

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Inflammation Imaging in Atherosclerosis2009 · 117 citations
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3Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis2015 · 264 citations
4Biodistribution and Radiation Dosimetry for the Chemokine Receptor CXCR4-Targeting Probe <sup>68</sup>Ga-Pentixafor2015 · 143 citations
5Tissue Classification as a Potential Approach for Attenuation Correction in Whole-Body PET/MRI: Evaluation with PET/CT Data2009 · 718 citations