What question did this study set out to answer?

To describe the phenotypic, biological, and clinical characteristics of hospitalized COVID-19 patients with diabetes and identify factors associated with mortality.

December 31, 2022Romanian Medical JournalOpen Access

Phenotypic characteristics and clinical outcome in hospitalized patients with COVID-19 and diabetes

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Authors

KPKostadin PoposkiPHI University Psychiatric Clinic - Skopje MBMile BosilkovskiSaints Cyril and Methodius University of Skopje KGKrsto GrozdanovskiAzerbaijan Medical University

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Implication

Retrospective study uncovers high mortality in hospitalized diabetic COVID-19 patients, highlighting age, unvaccinated status, and elevated lactate dehydrogenase as major lethal risk factors.

Key Points

To describe the phenotypic, biological, and clinical characteristics of hospitalized COVID-19 patients with diabetes and identify factors associated with mortality.
Conducted a single-center, retrospective study of 200 hospitalized patients with diabetes out of 1,119 total COVID-19 admissions.
Assessed primary endpoints of mortality at day 7, day 14, and beyond day 14 of hospitalization, using multivariate binary logistic regression to determine independent risk factors.
In-hospital mortality occurred in 46.5% of patients (93/200), with the majority of deaths occurring within the first 7 days of admission.
Non-survivors presented with significantly higher leukocyte counts, CRP, D-dimer, and LDH levels alongside more pronounced lymphopenia.
Multivariate analysis identified four independent risk factors for death: age (OR 1.05, 95% CI 1.01–1.09), disease severity at admission (OR 0.22, 95% CI 0.07–0.65), COVID-19 vaccination status (OR 3.07, 95% CI 1.36–6.91), and LDH levels (OR 1.00, 95% CI 1.002–1.008).

Cite This Study

Poposki et al. (2022) studied this question.

synapsesocial.com/papers/6a7eb3ede9bb045a73c2fd14 https://doi.org/10.37897/rmj.2022.4.6

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Implication

Retrospective study uncovers high mortality in hospitalized diabetic COVID-19 patients, highlighting age, unvaccinated status, and elevated lactate dehydrogenase as major lethal risk factors.

Phenotypic characteristics and clinical outcome in hospitalized patients with COVID-19 and diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Phenotypic characteristics and clinical outcome in hospitalized patients with COVID-19 and diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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