Altered pattern of sympathetic activity with the ovarian cycle in female smokers
Why the study?
Does smoking prevent the normal fall in muscle sympathetic nerve activity during the early follicular phase in premenopausal women?
Population
22 premenopausal women (11 smokers and 11 age-matched nonsmoking controls)
Comparison
Smoking vs Nonsmoking controls
Design
Cohort
Follow-up
one ovarian cycle
Authors
Discussion
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Implication
Potential mechanism for elevated CV risk in premenopausal smokers via sympathetic dysregulation; hypothesis-generating and should not yet change practice.
Structured PICO
Does smoking prevent the normal fall in muscle sympathetic nerve activity during the early follicular phase in premenopausal women?
P
Population
22 premenopausal women (11 smokers and 11 age-matched nonsmoking controls)
I
Intervention
Smoking
C
Comparator
Nonsmoking controls
O
Outcome
Change in muscle sympathetic nerve activity (MSNA) and blood pressure from the early follicular (EF) phase to the midluteal (ML) phasesurrogate
Smoking prevents the normal decrease in sympathetic nervous system activity during the early follicular phase of the ovarian cycle in premenopausal women, which may contribute to their increased cardiovascular risk.
Cite This Study
Park et al. (2009) studied this question.