Why the study?
Do prophylactic antibiotics reduce postoperative wound infection and death in patients undergoing colon surgery compared to no treatment?
Population
Patients undergoing colon surgery (based on 26 trials published from 1965 to 1980)
Comparison
Prophylactic antibiotic regimens vs No antibiotic treatment (no-treatment controls)
Design
Meta-analysis
Authors
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Supports prophylactic antibiotics as standard in colon surgery; precludes further no-treatment controlled trials.
Do prophylactic antibiotics reduce postoperative wound infection and death in patients undergoing colon surgery compared to no treatment?
Prophylactic antibiotics significantly reduce wound infections and mortality in colon surgery, demonstrating that the continued use of no-treatment control groups in such trials is no longer justified.
Anish et al. (1981) studied this question.
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