Coacervate-directed synthesis of CaCO ₃ microcarriers for pH-responsive delivery of biomolecules

microcarriers. Since this inorganic material exhibits high solubility in acids, the release of protein from the carriers can be controlled via the pH of the environment. The process results in the successful generation of bulk amounts of monodisperse and colloidally stable microspheres with diameters as small as 300 nm. As the entire synthesis takes place under aqueous conditions, coacervate-directed encapsulation is suitable for sensitive active agents. Accordingly, the method presents a promising approach to synthesize pH-responsive microcarriers for drug delivery applications.