Why the study?
Nonvitamin K antagonist oral anticoagulants require stricter medication adherence, prompting investigation into adherence patterns in real-world practice.
Does once-daily NOAC dosing improve medication adherence compared to twice-daily dosing in patients with atrial fibrillation?
Population
719 consecutive patients taking NOACs for atrial fibrillation
Comparison
Once-daily vs twice-daily dosing groups
Design
Cross-sectional study
Authors
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Once-daily NOAC dosing was associated with slightly higher adherence but should not yet change practice; leaves open whether the difference is clinically meaningful.
Does once-daily NOAC dosing improve medication adherence compared to twice-daily dosing in patients with atrial fibrillation?
Once-daily NOAC dosing is associated with slightly higher adherence than twice-daily dosing, though overall adherence is excellent for both regimens in real-world practice.
Hwang et al. (2019) studied this question.
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