What question did this study set out to answer?

To evaluate the biological roles of the matricellular protein periostin in respiratory diseases and assess its potential as a clinical biomarker of disease progression and targeted therapy response.

January 12, 2016American Journal of Respiratory and Critical Care MedicineOpen Access

Roles of Periostin in Respiratory Disorders

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Authors

KIKenji IzuharaSaga University SCSimon J. ConwayPediatric Cardiology BMBethany B. MooreUniversity of Michigan

Discussion

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Overview

Review demonstrates the pathogenic and biomarker utility of periostin in respiratory disorders, highlighting its value for predicting targeted therapy response and disease progression.

Key Points

To evaluate the biological roles of the matricellular protein periostin in respiratory diseases and assess its potential as a clinical biomarker of disease progression and targeted therapy response.
Narrative synthesis of preclinical and clinical studies examining periostin signaling cascades and airway remodeling in pulmonary pathophysiology.
Evaluation of clinical trial data investigating serum periostin levels as predictive biomarkers for response to anti-IL-13 and anti-IgE biologic treatments.
In asthma, periostin expression is stimulated by IL-13 and IL-4 in bronchial epithelial cells, mediating subepithelial fibrosis, mucus hypersecretion, and progressive lung function decline.
Serum periostin effectively identifies asthmatic patients who gain enhanced clinical benefit from targeted biologic therapies, including lebrikizumab, tralokinumab, and omalizumab.
Periostin is markedly upregulated in the lungs of patients with idiopathic pulmonary fibrosis, where peripheral blood levels correlate with and predict clinical disease progression.

Cite This Study

Izuhara et al. (2016) studied this question.

synapsesocial.com/papers/6a7ebe3fd93698698fb99158 https://doi.org/10.1164/rccm.201510-2032pp

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January 12, 2016American Journal of Respiratory and Critical Care MedicineOpen Access

Roles of Periostin in Respiratory Disorders

View Full Paper

Ask AI

Bookmark

Authors

KIKenji IzuharaSaga University SCSimon J. ConwayPediatric Cardiology BMBethany B. MooreUniversity of Michigan

Discussion

Member takes

Overview

Review demonstrates the pathogenic and biomarker utility of periostin in respiratory disorders, highlighting its value for predicting targeted therapy response and disease progression.

Key Points

To evaluate the biological roles of the matricellular protein periostin in respiratory diseases and assess its potential as a clinical biomarker of disease progression and targeted therapy response.
Narrative synthesis of preclinical and clinical studies examining periostin signaling cascades and airway remodeling in pulmonary pathophysiology.
Evaluation of clinical trial data investigating serum periostin levels as predictive biomarkers for response to anti-IL-13 and anti-IgE biologic treatments.
In asthma, periostin expression is stimulated by IL-13 and IL-4 in bronchial epithelial cells, mediating subepithelial fibrosis, mucus hypersecretion, and progressive lung function decline.
Serum periostin effectively identifies asthmatic patients who gain enhanced clinical benefit from targeted biologic therapies, including lebrikizumab, tralokinumab, and omalizumab.
Periostin is markedly upregulated in the lungs of patients with idiopathic pulmonary fibrosis, where peripheral blood levels correlate with and predict clinical disease progression.

Cite This Study

Izuhara et al. (2016) studied this question.

synapsesocial.com/papers/6a7ebe3fd93698698fb99158 https://doi.org/10.1164/rccm.201510-2032pp

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