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April 21, 2011Investigative Ophthalmology & Visual ScienceOpen Access

Increased Expression of Periostin in Vitreous and Fibrovascular Membranes Obtained from Patients with Proliferative Diabetic Retinopathy

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Population

Patients with proliferative diabetic retinopathy undergoing vitrectomy and 31 control eyes with macular hole…

Design

Cross-sectional

Authors

SYShigeo YoshidaKurume UniversityKIKeijiro IshikawaKyushu UniversityRARyo AsatoKyoto Medical Center

Discussion

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Overview

Elevated vitreous periostin in PDR supports further investigation as a target; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
Patients with proliferative diabetic retinopathy (PDR) undergoing vitrectomy (106 vitreous samples and 15 fibrovascular membranes) and 31 control eyes with macular hole or epiretinal membrane.
C
Comparator
Control retinas and vitreous from patients with macular hole or epiretinal membrane.
O
Outcome
Periostin mRNA and protein expression levels in fibrovascular membranes and vitreous.surrogate

Periostin is highly expressed in fibrovascular membranes and vitreous of patients with proliferative diabetic retinopathy, suggesting a role in its pathogenesis.

Cite This Study

Yoshida et al. (2011) studied this question.

synapsesocial.com/papers/6a7ebe45d93698698fb9915bhttps://doi.org/10.1167/iovs.10-6625
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