What question did this study set out to answer?

To investigate whether blood levels of marine omega-3 fatty acids are associated with changes in leukocyte telomere length over 5 years in patients with stable coronary artery disease.

January 19, 2010JAMAOpen Access

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

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Authors

RFRamin Farzaneh‐FarUppsala University

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Implication

Prospective cohort study shows higher marine omega-3 levels slow telomere shortening in coronary artery disease, suggesting a cellular mechanism for cardiovascular protection.

Key Points

To investigate whether blood levels of marine omega-3 fatty acids are associated with changes in leukocyte telomere length over 5 years in patients with stable coronary artery disease.
Prospective cohort study of 608 ambulatory outpatients with stable coronary artery disease recruited from the Heart and Soul Study in California and followed for a median of 6.0 years.
Measured baseline blood levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), as well as leukocyte telomere length at baseline and after 5 years.
Assessed associations using multivariable linear and logistic regression models adjusted for established cardiovascular risk factors and potential confounders.
Individuals in the lowest quartile of DHA+EPA experienced faster telomere shortening (0.13 T/S units over 5 years; 95% CI, 0.09–0.17) compared to those in the highest quartile (0.05 T/S units; 95% CI, 0.02–0.08; P < .001 for linear trend).
Levels of DHA+EPA were inversely associated with telomere shortening after multivariable adjustment (adjusted beta x 10^-3 = 0.05; 95% CI, 0.01–0.08).
Each 1-SD increase in DHA+EPA levels was associated with a 32% reduction in the odds of telomere shortening (adjusted OR, 0.68; 95% CI, 0.47–0.98).

Cite This Study

Ramin Farzaneh‐Far (2010) studied this question.

synapsesocial.com/papers/6a7ec5d3d93698698fb99266 https://doi.org/10.1001/jama.2009.2008

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Implication

Prospective cohort study shows higher marine omega-3 levels slow telomere shortening in coronary artery disease, suggesting a cellular mechanism for cardiovascular protection.

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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