Why the study?
Does lemildipine affect renal hemodynamics and the tubuloglomerular feedback mechanism in spontaneously hypertensive rats?
Population
Anesthetized 9- to 10-wk-old spontaneously hypertensive rats (SHR)
Comparison
Lemildipine 3 micrograms.kg-1 i.v. and 9… vs Control
Design
Preclinical
Authors
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May support renal protection in hypertensive models; leaves open translation to human therapy.
Does lemildipine affect renal hemodynamics and the tubuloglomerular feedback mechanism in spontaneously hypertensive rats?
In a preclinical model of hypertension, lemildipine maintained glomerular capillary hydrostatic pressure and GFR despite reduced renal perfusion pressure by attenuating the tubuloglomerular feedback response.
Kawabata et al. (1998) studied this question.
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