Why the study?
Do different dihydropyridine-type calcium antagonists have disparate effects on afferent and efferent arteriolar vasodilation in isolated perfused kidneys?
Population
Isolated perfused hydronephrotic kidneys
Comparison
Dihydropyridine-type calcium antagonists at… vs Angiotensin II- and norepinephrine-induced renal…
Design
Preclinical
Authors
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Animal data suggest efonidipine may benefit glomerular hypertension; leaves open human translation and outcomes.
Do different dihydropyridine-type calcium antagonists have disparate effects on afferent and efferent arteriolar vasodilation in isolated perfused kidneys?
Efonidipine, unlike other dihydropyridine calcium antagonists, dilates both afferent and efferent renal arterioles, potentially offering advantages in ameliorating glomerular capillary hypertension.
Hayashi et al. (1996) studied this question.
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