What question did this study set out to answer?

To develop an injectable, thermosensitive hydrogel system for localized intramyocardial delivery of colchicine to promote tissue repair after myocardial infarction while mitigating systemic toxicity.

December 31, 2019Journal of Materials Chemistry B

An injectable thermosensitive hydrogel loaded with an ancient natural drug colchicine for myocardial repair after infarction

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Why the study?

Colchicine has potent anti-inflammatory effects for MI repair, but its clinical use is limited by severe systemic toxicity and a narrow therapeutic window.

Does intramyocardial delivery of colchicine via a thermosensitive hydrogel improve cardiac repair and survival without severe systemic toxicity in a mouse model of myocardial infarction?

Population

Mouse model of MI and in vitro cell tests

Comparison

Intramyocardial Col@Gel vs intraperitoneal Col solution

Design

Preclinical in vitro and animal experimental study

Authors

YCYu ChenTongji University JSJiayue ShiTianjin Normal University YZYaping ZhangNantong University

Discussion

Member takes

Implication

Hypothesis-generating for localized colchicine after MI; leaves open human translation and should not yet change practice.

Key Points

To develop an injectable, thermosensitive hydrogel system for localized intramyocardial delivery of colchicine to promote tissue repair after myocardial infarction while mitigating systemic toxicity.
Formulated a thermosensitive PLGA-PEG-PLGA polymer hydrogel loaded with colchicine (Col@Gel) that exhibits a sol-gel transition at 35 °C and sustains drug release for over 8 days.
Evaluated the in vitro inhibitory effects of Col@Gel on macrophage proliferation and migration.
Administered a single intramyocardial injection of Col@Gel in a mouse model of myocardial infarction to evaluate cardiac inflammation, apoptosis, fibrosis, cardiac function, and survival compared to systemic colchicine.
Col@Gel effectively inhibited macrophage proliferation and migration in vitro.
In infarcted mice, intramyocardial Col@Gel significantly reduced cardiac inflammation, apoptosis, and fibrosis while improving cardiac structure, function, and survival rates.
Localized hydrogel delivery prevented the severe systemic toxicity observed with standard intraperitoneal administration of colchicine solution.

Structured PICO

Does intramyocardial delivery of colchicine via a thermosensitive hydrogel improve cardiac repair and survival without severe systemic toxicity in a mouse model of myocardial infarction?

Population

Mouse model of myocardial infarction and in vitro macrophage cell tests

Intervention

Single intramyocardial administration of colchicine loaded in a thermosensitive PLGA-PEG-PLGA polymer hydrogel (Col@Gel)

Comparator

Intraperitoneal administration of colchicine solution

Outcome

Cardiac inflammation, myocardial apoptosis and fibrosis, cardiac function and structure, and mouse survivalsurrogate

A novel thermosensitive hydrogel for localized intramyocardial delivery of colchicine improves cardiac repair and survival in a mouse model of MI while avoiding systemic toxicity.

Cite This Study

Chen et al. (2019) studied this question.

synapsesocial.com/papers/6a7ec6802540bc8e230269db https://doi.org/10.1039/c9tb02523e

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An injectable thermosensitive hydrogel loaded with an ancient natural drug colchicine for myocardial repair after infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

An injectable thermosensitive hydrogel loaded with an ancient natural drug colchicine for myocardial repair after infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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